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Themed collection Coronavirus articles - free to access collection

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Editorial

Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research

unique
Shares in Hyundai and AmorePacific slid on Friday, down 4.4 per cent and 12.5 per cent respectively in late afternoon trading in Seoul.

Graphical abstract: Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial

Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?

Li Yi, a Shanghai-based independent IT expert, told the Global Times the surge in the number of smartphones was the primary reason for the growth in Net users.
Among the amenities spread through its three terminals are two 24-hour movie theaters screening the latest blockbusters for free, a rooftop swimming pool and a butterfly garden.

Graphical abstract: Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Open Access Accepted Manuscript - Highlight

Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities

Open Access Perspective

Soft matter science and the COVID-19 pandemic

“…was checking his cell phone and chewing gum during the meeting.”

Graphical abstract: Soft matter science and the COVID-19 pandemic
Open Access Perspective

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

Best Companies rank: 11

Graphical abstract: Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Perspective

Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic

美国航天局(Nasa)表示,2015年气温以0.13摄氏度之差,打破了2014年创下的记录。
《火星救援》获评喜剧/音乐类最佳影片。
问:在过去的几次采访中,你都提到了你和角色之间的联系。那么在目前播放的Aldnoah Zero重,你觉得你和伊奈帆之间的联系是什么?
As US ETF assets under management passed the $3tn mark this summer, AUM in the Asia-Pacific industry just managed to creep over $350bn.

Graphical abstract: Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Perspective

Trends and targets in antiviral phototherapy

Sorry, folks, but if you're an investor hoping America's political internecine wars will improve in the near future, just don't invest. The war between Congress with it's abysmal 10% approval rating and the president, the war between the Dems, GOP and the tea party, is going to get even worse, upsetting markets and the economy even more.
但随着美国接近实现充分就业,随着通胀向目标水平趋近,“你可以看到收紧政策是有道理的,”他说,“不需要很多就足以改变整个平衡”。
n. 面具,面罩,伪装
持续推进大众创业、万众创新。

Graphical abstract: Trends and targets in antiviral phototherapy
Minireview

A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays

Christmas arrived on schedule for the U.S. auto industry as a spurt of sales put the wrapping on a surprisingly successful year. Analysts predicted that sales in December could hit a seasonally-adjusted rate of 17 million, which would be the first month at that rate in nearly six years. That would push 2013 sales up to a robust 15.7 million units.

Graphical abstract: A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Minireview

Novel biosensing methodologies for ultrasensitive detection of viruses

tri三+angle角→三角形

Graphical abstract: Novel biosensing methodologies for ultrasensitive detection of viruses
Application

Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug

worthwhile
China has all long and continues to support a united, prosperous and stable European Union, support a strong Euro, and support European integration process. We believe that is good for globalization, for a multipolar world and for diversity of civilizations. We feel optimistic about the future of the EU and the future of China-EU relations.

Graphical abstract: Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Open Access Review Article

ACE2 as a potential therapeutic target for pandemic COVID-19

Successful entrepreneurs often worked for others in their field of choice before striking out on their own. Spending a few years in the industry under an excellent mentor will provide a good launching pad. Learn from your predecessors’ mistakes and brainstorm about how to improve upon their model. Find someone willing to teach, and think about starting your business elsewhere when you leave.
“美联储比外界所预期的更加咄咄逼人,”克普克表示,“让市场感到意外显然并非上策。”(那时美联储尚未建立在货币政策会议后发布公开声明的制度。)

Graphical abstract: ACE2 as a potential therapeutic target for pandemic COVID-19
Open Access Review Article

Diagnostic technologies for COVID-19: a review

布雷克·格里芬
商务部本月早些时候表示,消费品的零售销售是去年消费的一项关键指标。该销售额同比增长了10.7%,占去年全国66.4%的GDP增长。

Graphical abstract: Diagnostic technologies for COVID-19: a review
Open Access Review Article

Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review

Perhaps my favorite profile this year was Kiki Zhao’s stirring depiction of the remarkable Yu Xiuhua, now one of China’s most read poets, a woman with cerebral palsy who lived most of her 41 years on a farm, writing at a low table. She never finished high school, and says she “could write before she could read.” Now, she is invited to places like Stanford University and fends off comparisons to Emily Dickinson.
In 2007, Apple released the first iPhone: a full touchscreen phone, complete with its own virtual keypad. To many, Apple had done something new, something never seen before. They had made the first touchscreen phone. But this was incorrect: Apple did not make the first touchscreen phone, nor was the touchscreen a new invention.
据当地媒体报道,这一犯罪团伙设在广西壮族自治区首府南宁,他们向腐肉中注射化学药品,使其增重50%,这样每吨腐肉便可获利16000元人民币(合1750英镑)。
“He is very, very good at not allowing that pressure to in any way disrupt what Apple is trying to achieve,” says Mr Iger. “Clearly there were issues that were on his mind but Tim made sure they were never on the minds of the people who do what Apple does best.”

Graphical abstract: Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Open Access Review Article

An overview of key potential therapeutic strategies for combat in the COVID-19 battle

以美元值计,11月中国的出口总值同比上升12.3%,比10月的出口总值同比增速6.9%有所提高,高于路透社(Reuters)调查的经济学家给出的预测中值5%。

Graphical abstract: An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Open Access Review Article

Potential repurposed SARS-CoV-2 (COVID-19) infection drugs

Don't ever tell me that you have to have this job because you're going to lose your house, your kids have nothing to eat, your mother has cancer. Companies aren't a charity.
8 April

Graphical abstract: Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Open Access Review Article

Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale

韩国最大的整形医院之一,由权株创立的JK整形手术中心,近期开了一家旅馆来更好地服务顾客。这些顾客每次看病人均花费17675美元。

Graphical abstract: Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Review Article

In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections

她还指出,其他国家在其货币贬值的同时呈现出旅客数量的大幅增加。

Graphical abstract: In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Review Article

Antiviral drug discovery: broad-spectrum drugs from nature

As part of its 2014 capital plan, the San Francisco, Calif.-based bank said it would increase its buybacks by 350 million shares, or a total of almost $17 billion. It also boosted its dividend rate by about 17% to $0.35 a share.
我更愿意和别人保持距离
以下10种妖魔就像无人机一样,瞄准了股市、债市和世界经济:
radiation

Graphical abstract: Antiviral drug discovery: broad-spectrum drugs from nature
Review Article

Influenza neuraminidase: A druggable target for natural products

British schools outperform the French on both new criteria. Warwick Business School, the top UK school for career progress, is second overall for the criterion, 30 places above the first French school, HEC Paris. Alumni from UK schools also see a higher increase between their first salary after graduation and now, at 62 per cent versus 45 per cent. However, UK school alumni still have a lower salary on average than their counterparts who studied in France, at $55,000 versus $64,000.
*喜剧类最佳客串女演员:蒂娜?菲(Tina Fey)和艾米?波勒(Amy Poehler),《周六夜现场》(Saturday Night Live)
4.阿迪达斯。品牌喜爱度:35%/排名:25
2017年排行榜的前几名几乎清一色都是法国商学院。校区位于里尔和尼斯的北方高等商学院(Edhec Business School)首次登上该榜单榜首。自2011年该榜单编制以来一直排名第一的巴黎高等商学院(HEC Paris)如今降至第二名。
13. iPhone Reminders

Graphical abstract: Influenza neuraminidase: A druggable target for natural products
Critical Review

Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle

"At a time when the world seems defined by division, storytellers bring us together as one," AFI president and CEO Bob Gazzale said Thursday in a statement. "AFI Awards is honored to celebrate this community of artists who challenge and inspire us, entertain and enlighten us - ultimately reminding us of our common heartbeat."
The survey is based on costs of over 160 items ranging from food and clothing, to domestic help, transport and utilities.

Graphical abstract: Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
Critical Review

The role of biosensors in the detection of emerging infectious diseases

Meanwhile, he was being ferried around the globe to tech conferences, getting introduced to other potential investors. D'Aloisio made a remarkable impression on everyone he crossed paths with. 'He has an eerie maturity,' says Andrew Halls, headmaster of the King's College School in Wimbledon, which D'Aloisio has attended since he was 11. 'He has an extraordinary articulateness in the face of situations that, for me, even as a 54-year-old, might be terrifying.'

Graphical abstract: The role of biosensors in the detection of emerging infectious diseases
Communication

Quantitative determination of mechanical stability in the novel coronavirus spike protein

The crown passed from the Plantagenet dynasty to the Tudor monarchs who painted Richard as a deformed villain who stopped at nothing in his quest for power, even murdering his two young nephews -- the so-called Princes in the Tower -- to secure the throne.

Graphical abstract: Quantitative determination of mechanical stability in the novel coronavirus spike protein
Communication

Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations

Deciding what to blog about can become time consuming. HitTailanalyzes the data in your Google Webmaster Tools account and makes recommendations for long-tail words to write about. In addition, HitTail has a network of skilled writers who can create the content for you.
Song “Beautiful China”(Sha Baoliang and Xu Qianya)
她还指出,其他国家在其货币贬值的同时呈现出旅客数量的大幅增加。
China’s commercial aerospace ambition has long been known, but a few recent milestones are bringing it closer to realization.

Graphical abstract: Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Communication

MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling

未来数年时间内,截止2018年,支出将上升至1.3万亿美元。而1000亿美元的丙型肝炎药物支出及同等的癌症治疗费用,还有780亿美元的糖尿病治疗费用都将是构成支出上升的因素。
在中国北方分析出的这种病毒与1957年以前传播的病毒相似,因此,1957年以前出生的人一般都有了抵抗力,而在那年之后出生的儿童和年轻人由于没有预先的免疫力而缺乏抵抗力。1978年这种病毒在世界各地传播开来,其中包括美国。这种病主要发生在孩子们身上,因此,这次流感没被看成是真正的大流行。1977-78年的流感季节,还没有及时地生产出控制病毒的疫苗,但是,1978-79年的流感疫苗就包含了这种病毒的疫苗。
Emma Thompson, a two-time winner for Howards End and Sense and Sensibility, famously keeps hers in the loo: “They look far too outré anywhere else. They’re great big, gold, shiny things.” She’s not alone – Susan Sarandon, Lionel Richie and Sean Connery all claim to keep their golden fellas alongside their bidets and baths.
Gymnastics;Trampoline;Artistic gymnastics;Rhythmic gymnastics

Graphical abstract: MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
From the themed collection: 增值税改革,全年减税超万亿元
Communication

Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses

Wang Ki-young, a director at South Korea’s culture ministry, said on Friday that Chinese authorities had ordered tourism agencies in Beijing to halt tours to South Korea from mid-March. Mr Wang said the move would be expanded to other provinces.
就算利润率更低(比如40%),并且替代率为1/3(即全价iPhone的客户流失三分之一),低价iPhone也能提高苹果的营收和毛利润(见上表)。

Graphical abstract: Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Communication

Inhibition of SARS coronavirus helicase by bismuth complexes

《善地》
['?unip]
上海复旦大学社会发展与公共政策学院院长彭希哲周二告诉环球时报,在产业结构升级的过程中,劳动密集型产业搬离都市圈,是导致这一人口变迁的最主要原因之一。
盘点2011秋季美剧10大最性感女性角色
"The Chinese government, universities and investors have provided a friendly environment for young startups. However, the failure rate of fresh graduates founding startups is still too high due to the lack of experience, resources and networking," said Wang Yixin, a senior consultant at Zhaopin.

Graphical abstract: Inhibition of SARS coronavirus helicase by bismuth complexes
Open Access Edge Article

Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning

con共同,duct引导-引导大家的行为举止
Zhou Qunfei from Lens Technology, the major touchscreen maker, ranks third on the list with a net worth of 45 billion yuan.
encouragement

Graphical abstract: Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Open Access Edge Article

A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers

Wonder Woman
Followers are also getting younger and better educated, with 77.8 percent in the 17-to-33 age group and 75 percent with a higher education.

Graphical abstract: A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
From the themed collection: 天津人才新政背后的楼市
Open Access Edge Article

Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods

The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.

Graphical abstract: Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
Open Access Edge Article

Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors

By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.

Graphical abstract: Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
Open Access Edge Article

Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir

该学院还在国际课程体验方面排名第二。在最新的毕业生当中,逾五分之四的人有过国外实习经历,逾一半学员有过在另一个国家学习超过一个月的经历。
其他人将想方设法利用技术来帮助人们减少上网时间。谷歌(Google)前雇员特里斯坦哈里斯(Tristan Harris)发起的“时光莫虚度”(Time Well Spent)运动正在吸引人气,该运动鼓励设计者理解他们所控制的微妙的心理力量,以解决其所称的“数字注意力危机”。据Recode报道,曾经在Pinterest和Facebook工作的蒂姆肯德尔(Tim Kendall),计划成立一家专注于对抗设备上瘾的初创公司。
HSBC economist Hongbin Qu said the survey pointed to lost momentum in China's manufacturing sector: He expects Beijing to respond with measures to counteract the slowdown.

Graphical abstract: Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Open Access Edge Article

Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes

The bulk was due to underlying global warming caused largely by rising emissions of carbon dioxide, the main man-made greenhouse gas produced by burning fossil fuels, such as coal and oil.
"I heard from several business leaders who shared their concern about our relative silence and impact in urging the political leadership to act on behalf of the citizenry," Schultz wrote in a letter on his company's website.
Common and Day will perform "Stand Up For Something" from "Marshall" and Settle will perform "This is Me" from "The Greatest Showman."

Graphical abstract: Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Accepted Manuscript - Paper

A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring

Open Access Paper

Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)

This means war: Christopher Nolan's second film not set in the present (or future) is an epic tableau about the rescue of hundreds of thousands of troops from the French coast. Tom Hardy, Mark Rylance, Kenneth Branagh, Cillian Murphy and, er, Harry Styles, star. Think Saving Private Ryan, but saltier.

Graphical abstract: Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Paper

A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood

The people of both countries have the wisdom to properly manage their differences, there is a need and there are also conditions for us to continue to expand our common interests.

Graphical abstract: A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Open Access Paper

Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations

But once again, Bryant said he's fine, that his health is fine, that his shot is fine, and he diverted the conversation elsewhere, largely to his teammates and the team's overall scheme.
shoulder

Graphical abstract: Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Open Access Paper

The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives

28 September
Fifteen Chinese nationals have been charged with developing a fraud scheme in which they paid imposters to take entrance exams, including the SAT, and gained acceptance to elite American colleges and universities, the US Department of Justice said on Thursday. Conspirators were paid up to $6,000 each time they used counterfeit Chinese passports to trick test administrators into thinking they were the person who would benefit from the test score, a federal grand jury charged.重点单词
在波尔多足球场外,一个欢闹的视频中摇摆的人群对着一名笑着的年轻女子大唱“Can’t Take My Eyes Off You and Hey Baby”。
In a bid to change their looks, 20 percent of women between the ages of 19 and 49 in Seoul, the country's capital city, admitted they had gone under the knife.

Graphical abstract: The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Open Access Paper

Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease

预测:达福目前可能是最佳男配角的领跑者。
[.di:m?'gr?fik]

Graphical abstract: Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Open Access Paper

Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro

Baoneng’s raid has been bitterly resisted by Wang Shi, Vanke’s founder who has sought out white knights in a so far successful effort to retain control of the management-led company. The takeover battle fuelled a surge both in the price of Vanke’s Shenzhen-traded shares and Mr Yao’s known worth.
Supporting Actor in a Comedy: Louie Anderson, “Baskets”

Graphical abstract: Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Open Access Paper

Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein

A powerful earthquake struck off Japan's southern coast on May 30, prompting fears in China of a catastrophe similar to the tsunami and Fukushima nuclear power plant meltdown that followed the 2011 Japanese quake. In the end, no fatalities or major damage were reported.

Graphical abstract: Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Paper

Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide

价值增长最快的品牌
西蒙接受本刊采访时说:“聘用老兵是我们做出的最好的决定之一。我们在阵亡将士纪念日推出了‘欢迎回家’计划,至今我们已经聘用了超过2.6万名老兵,让我们倍感骄傲。老兵在面对压力时表现一贯优秀,而且有服务热情,这些因素让我们很容易兑现聘用老兵、学习老兵和支持老兵的承诺。”
5.重播和比赛精彩集锦同主要现场比赛一样精彩,所以我也会看。
现年60岁的罗斯是位于波士顿的哈佛大学的教授,而89岁的沙普利是美国加州大学洛杉矶分校的教授。

Graphical abstract: Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Open Access Paper

Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses

这句简练、言之有物、几乎可称之为妙语的话提醒我们,即便接下来的奖项都相当雷人,还是有人能够做到直白的。
4. Rihanna

Graphical abstract: Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Open Access Paper

The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor

Trium在三个指标上名列第一:攻读课程前学员的工作经历、实现的目标,以及国际课程经历。该课程学员在毕业3年后的平均薪资排名第二(30.7003万美元),仅次于Kellogg/HKUST联合推出的课程。
I can't stop thinking that these children are my age, that it makes a tremendous difference where you are born, that I could be one of those children living in the Favellas of Rio; I could be a child starving in Somalia; a victim of war in the Middle East or a beggar in India. 我永远不能忘记这些和我同龄的孩子,当你出生的时候,他和我们真的很不相同,我也许生活在贫民窟,也可能是终日饿着肚子的小孩,也可能是中东战争的牺牲品,或者印度的小乞丐。
户外空间:从这座露台往下走几步就是一座带有草坪和喷泉、围着围墙的花园。这处房产面积0.10英亩(约405平方米)。

Graphical abstract: The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Open Access Paper

Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study

日本北海道——尽管北海道最初因作为滑雪胜地而闻名于世,那里的雪花洁白而细腻;但也许很快它的全年美景就会更为外国游客所熟知,而新修建的自东京驶来的高速列车应该会起很大作用。
Indeed, their ability to do so peacefully is among their strengths.
尽管2016年受调查机场的平均准点率同比提高7%至70.4%,但航班平均延误时长为33分钟。

Graphical abstract: Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Open Access Paper

Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework

adj. 连续的,继续的,连绵不断的
As a result, in the first 10 months of 2016, the year-on-year decline in EM exports in dollar terms was just 6.6 per cent, according to calculations by Capital Economics, a marked improvement on the 11.6 per cent contraction seen in 2015, as the third chart illustrates.

Graphical abstract: Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Open Access Paper

Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach

Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.

Graphical abstract: Several coumarin derivatives and their Pd(ii) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
From the themed collection: 广州“自愿不购买社保”条款无效
Open Access Paper

Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors

Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.

Graphical abstract: Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Open Access Paper

Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins

Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.

Graphical abstract: Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Open Access Paper

Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform

When asked if the central bank would do more, Dario Perkins, chief European economist at Lombard Street Research, said: “I don’t think so, unless something goes wrong in the wider global economy.”
The big question is what oil prices will do in 2015. Oil prices are unsustainably low right now – many high-cost oil producers and oil-producing regions are currently operating in the red. That may work in the short-term, but over the medium and long-term, companies will be forced out of the market, precipitating a price rise. The big question is when they will rise, and by how much.
随着他不断运用网络来搜集知识,达洛伊西奥意识到,他急需一个能让他快速确定文章阅读价值的方法。于是他构想了一个摘要工具,能运用语言学理论来编写低于400字的内容提要。

Graphical abstract: Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
From the themed collection: 安置房3号楼不到俩月土方过半
Open Access Paper

A modular microarray imaging system for highly specific COVID-19 antibody testing

清华大学的毕业生以毕业五年后平均月薪14822元高居榜首。39所高校生跻身万元户行列。此外,共有185所高校的毕业生平均月薪突破8000元大关,789所高校的平均月薪突破了6000元大关。
Two years ago, the AFI delayed voting on its year-end list to give critics a chance to see Star Wars: The Force Awakens, which it subsequently included on its list of the 10 best films of 2015. However, this year, the latest Star Wars film, The Last Jedi, which hits theaters on Dec. 15, was nowhere to be found on AFI's list.

Graphical abstract: A modular microarray imaging system for highly specific COVID-19 antibody testing
From the themed collection: 热点城市新房价格上月没涨
Open Access Paper

Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms

Mark Rutte, the Dutch prime minister whose People’s Party for Freedom and Democracy (VVD) is slightly ahead of the PVV, has seen his poll numbers rise in recent days because of his hardline stance with Ankara. On Tuesday he called Mr Erdogan’s comments “a disgusting distortion of history”, adding: “We will not lower ourselves to this level. It is totally unacceptable.”
In response, Mr Wilders labelled Mr Rutte a liar, citing the prime minister’s broken pledge not to support a bailout of Greece during the 2012 election.
Ranking third on our Top-Grossing list is Steve Carell. Despicable Me 2 was a huge hit this year, bringing in $919 million at the box office. Overall, the franchise has earned $1.4 billion at the box office worldwide and a third movie, Minions, is on the way. Carell also appeared this year in the small indie The Way Way Back and The Incredible Burt Wonderstone. The latter failed to earn back its production budget at the box office but we’re only looking at ticket sales here — the film put another $22.5 million in Carell’s column for 2013.

Graphical abstract: Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Open Access Paper

Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening

May you have the best New Year ever.

Graphical abstract: Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Open Access Paper

Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations

A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.

Graphical abstract: Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
Open Access Paper

Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets

Here's how the pay of prime ministers and presidents of the world's biggest economies stacks up, according to official data and converted into US dollars at market rates.
6. Photojournalist

Graphical abstract: Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Open Access Paper

A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation

但是随着朱迪-霍勒迪的回归和安东尼-戴维斯打出历史级别的数据,他们不会差到以至于能够得到上边提到的Fultz,Jackson之流。去年的选秀怎么就没那么好呢!
它把孩子的重量从您的后背转移到肩膀和腰腹部。

Graphical abstract: A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
Open Access Paper

An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19

3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.

Graphical abstract: An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
From the themed collection: 涂料市场今后将会如何发展
Open Access Paper

Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies

这些银行将钱返还给股东的能力有所下降。中央财经大学中国金融业研究中心主任郭田勇表示,缓慢的盈利增长和高额的不良贷款以及存款准备金给银行的资本金补充带来了压力。
While 221 people fell off the billionaires list this year, 198 people joined the ranks. Twenty-nine from the 2015 list died, while another 29 rejoined the list after having fallen off.

Graphical abstract: Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Paper

Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material

噢,卡梅隆,真希望你还有高中时的风采,因为那时的你是史诗般的存在。
The Swiss school came top of the list of 90 best masters programmes worldwide in 2016, winning its sixth consecutive crown.

Graphical abstract: Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Open Access Paper

A facile assay for rapid detection of COVID-19 antibodies

Hangzhou in Zhejiang Province and Shenzhen in Guangdong Province made the biggest progress in improving traffic with measures including vehicle restrictions and better road links, said the report.

Graphical abstract: A facile assay for rapid detection of COVID-19 antibodies
Open Access Paper

Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses

The demagogue’s campaign leads naturally to despotism — the tyranny of the majority that is a mask on the tyranny of one.
披露表格还警告购汇者不得使用其他人的购汇额度。以前,灰色市场的货币兑换者经常把多个个人的购汇额度汇集起来,靠这种手段来获取大量外汇。
中国(大陆及香港)在排行榜上新添了25个成员,增长数量超过其他任何国家,共计207家。三个国家今年首次在排行榜上亮相了:毛里求斯、斯洛伐克以及多哥。
一楼还有一间书房,这间房有黑色的护壁板,还有一座壁炉。厨房里有花岗岩台面,四周墙面贴有瓷砖,并配了一些不锈钢的电器,地上铺着方格地板。这里的法式双开门通往一处露台。

Graphical abstract: Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Open Access Paper

Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2

3.你老板从他认识的人那收到了你认识的人给的简历。

Graphical abstract: Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Open Access Paper

Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease

今年,我最喜欢的人物报道可能是Kiki Zhao对中国目前读者最多的诗人之一余秀华激动人心的描写。余秀华是一个了不起的人。她患有脑瘫,过去41年里大部分时间生活在农村,在一张矮桌子上写作。高中没毕业的她说自己“在能读它们(名著)之前,我就知道如何写作了”。现在,她受邀前往斯坦福大学等地,她不愿被比作艾米丽·迪金森(Emily Dickinson)。
Plenty of technology companies are angling for a piece of the action, from established players such eBay’s Magento , IBM , and NetSuite to smaller developers including Shopify and Volusion. But relative underdog Bigcommerce is stealing mindshare and market share, fueled by more than $75 million in venture capital, including $40 million from entrepreneur Steve Case’s Revolution Growth firm.
野村证券驻首尔策略师Michael Na表示:“这可能只是个开始。要惩罚韩国企业,他们有如此多的选项。”

Graphical abstract: Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Open Access Paper

Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19

China Mobile, supply chain rumors are emerging about Apple’s next significant product releases. Digitimes reports that according to “sources from the upstream supply chain, ” Apple is planning to release a 5-inch iPhone 6 “phablet” this coming May and a large tablet in October.
“…fell asleep.”

Graphical abstract: Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
From the themed collection: 全国房贷利率连续18个月上涨
Paper

Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties

2017年最佳国家瑞士首度排名第一。瑞士以中立而闻名,“乐于谈生意”排名第三,“公民权益”排名第三。
[k?n'gr?tju.leit]

Graphical abstract: Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
From the themed collection: 产权制度改革释放经济增长活力
Open Access Paper

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.

Graphical abstract: Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Paper

Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract

在欧洲所有商学院中,高管MBA校友在毕业3年后的平均薪资为14.3万美元,管理硕士毕业生为5.4万美元。MBA毕业生平均薪资为12.3万美元。西班牙和德国的管理硕士毕业生在毕业3年后的薪资最高,均为平均7万美元。法国MBA毕业生和瑞士EMBA毕业生的薪资最高,平均薪资分别为13.7万美元和16.6万美元。

Graphical abstract: Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Open Access Paper

Anti-HIV drug repurposing against SARS-CoV-2

此外,今年有66位40岁以下的富豪入选,创下了该榜单的记录,诺依曼,希伯尔曼和夏普三人位列其中。
Yes, you want to know how to do most of your job. But there are also things you want to be learning; otherwise you are not growing professionally. If you have stopped learning at work, it's time to find a job where you will learn new skills and grow professionally.
2016年,我们看到很多新设备加入互联网(不幸的是,我们也看到他们被黑客打倒了大片)。从家用电器到服装,公司很想出售一些能使你的生活“智能化”的产品,但有时反而会适得其反。让我们来回顾在过去的一年里出现的一些最荒谬和最无用的互联网连接设备。

Graphical abstract: Anti-HIV drug repurposing against SARS-CoV-2
From the themed collection: 北京商住房限购两年成交量下跌94%
Paper

Length-scale dependence of protein hydration-shell density

Believe it or not, this prize went to the US Government General Accountability Office (GAO) for issuing a report that recommended a report about another report of reports recommending reports... or something like that.
Traders heading for the exits: 'Unsustainable trends can survive much longer than most people anticipate, but they do end when their 'time is up, at the culmination of their time cycles.' They analyzed more than 20 cycles: 'Nearly unanimously point to tectonic shifts in the months and years ahead.'
na;F(|GWK@bR)
One of the highest-paid Bollywood actresses, Deepika Padukone hold the third position in the list of 10 most beautiful women of 2015. She is considered a sex symbol and style icon in India. Padukone ranks high on various listings of the most attractive Indian women. She is cited by her figure, height, smile, and eyes as her distinctive physical features. She is an active celebrity endorser for several brands and products, including Tissot, Sony Cyber-shot, Nescafe, Vogue eyewear, Maybelline and Pepsi, among others.

Graphical abstract: Length-scale dependence of protein hydration-shell density
Open Access Paper

High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus

According to a report by Beijing Statistics Bureau, retail sales of consumer goods in the Chinese capital surpassed 1 trillion yuan ($152 billion) in 2015, up 7.3 percent year on year.
[swift]

Graphical abstract: High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Paper

A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor

[in'k?rid?]
跳水游泳花样游泳篮球小轮车曲棍球田径
伦敦——在20世纪70年代,英国喜剧演员汤米·库珀(Tommy Cooper)讲过这样一个笑话:他在阁楼里发现一把小提琴和一幅画,让拍卖公司估价。拍卖公司说,好消息是它们分别出自斯特拉迪瓦里(Stradivarius)和伦勃朗(Rembrandt)之手。坏消息是那幅画是斯特拉迪瓦里画的,小提琴是伦勃朗做的。

Graphical abstract: A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
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夏季期间,中国股市泡沫破裂,数万亿美元的市值因而蒸发。尽管政府作了大量努力遏制股市暴跌,上海证券综合指数仍由7月12日的峰值一路下滑,到8月26日时下跌了43%。
据此网站统计,排名第二的慈善明星是前迪斯尼明星后转型歌手的麦莉塞勒斯。准爸爸查宁塔图姆名列第三。

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