Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
在定制课程排行榜上，排在第二名瑞士洛桑国际管理发展学院之后的是杜克企业教育学院(Duke Corporate Education)。这是这所美国学校连续第3年位列第三。该校在2014年连续第12年占据定制课程排行榜榜首位置，创下纪录。
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Skeptics of climate change have long argued that global warming stopped around 1998, when an unusually powerful El Ni?o produced the hottest year of the 20th century. Some politicians in Washington have seized on that claim to justify inaction on emissions.
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Barrymore's condition was based on the real life of Michelle Philpots, who suffered head trauma in two separate motor vehicle accidents, which left her with a 24-hour memory. Rather than using Sandler's tapes, Philpots has survived for over 23 years using Post-it notes and her (amazingly modern, from her perspective) mobile phone.
Starbucks CEO Howard Schultz
Trends and targets in antiviral phototherapy
In this Jan. 15, 2008, file photo, Apple CEO Steve Jobs holds up the new MacBook Air after giving the keynote address at the Apple MacWorld Conference in San Francisco
This is not to take anything away from Tesla, which has demonstrated that it can create and manufacture a complex and sophisticated product with demonstrated customer appeal. But its own internal forecasts, as well as the swelling of its share price, are based on the expectation that the future will unspool in an orderly fashion identical to the recent past. That’s a dangerous assumption to make – for several reasons:
Despite the huge production, the focus was on the 40 gorgeous models who walked the runway.
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Novel biosensing methodologies for ultrasensitive detection of viruses
There has also always been a certain fluidity to this concept of whiteness. Irish and Italian immigrants to the United States, and Jews in Britain, were once seen as separate from the white national majority, and are now generally considered part of it, benefiting from racial privilege. At the same time, Jews’ white skin did not protect them from being cast as outsiders by some of Mr. Trump’s supporters who have circulated anti-Semitic memes on social media.
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
ACE2 as a potential therapeutic target for pandemic COVID-19
Diagnostic technologies for COVID-19: a review
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Isolated in northern China, this virus was similar to the virus that spread before 1957. For this reason, individuals born before 1957 were generally protected, however children and young adults born after that year were not because they had no prior immunity. By January 1978, the virus had spread around the world, including the United States. Because illness occurred primarily in children, this event was not considered a true pandemic. Vaccine containing this virus was not produced in time for the 1977-78 season, but the virus was included in the 1978-79 vaccine.
The ECB ended the year with a vote on December 3 to cut its deposit rate to minus 0.3 per cent and an expansion in asset purchases that leaves its quantitative easing programme at 1.46tn. The move came days before the US Federal Reserve increased interest rates for the first time since 2006, underlining the sharply divergent policies being pursued on either side of the Atlantic.
“With the vast number of cutting-edge, eco-friendly faux furs available on the market today, I'm sure you'll agree that there's no longer any excuse for killing animals for their fur.”
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Yes, 2014 is an absolute total disaster just waiting to ignite. In 'Doomsday poll: 87% risk of stock crash by year-end' we analyzed 10 major crash warnings since early this year. Since then, more incoming bogies raced across our radar screen. Ticking time bombs from Congress, the Supreme Court, sex, carbon emissions, Big Oil, NSA, IRS, Tea Party austerity. Relentless. Mind-numbing.
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Promote all-round economic, political, cultural, social, and ecological progress
1."The Little Kicks" in Seinfeld Almost Didn't Happen
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Antiviral drug discovery: broad-spectrum drugs from nature
Influenza neuraminidase: A druggable target for natural products
The next step? Jalava plans to upgrade the finger with an RFID tag and add wireless support. He also wants to add more memory, which seems pointless to us. If he needs more storage, he has nine other fingers he can chop off and replace with flash drives.
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
The role of biosensors in the detection of emerging infectious diseases
Quantitative determination of mechanical stability in the novel coronavirus spike protein
While at least four engines tend to repeat from one year’s 10 best list to the next, only two of last year’s powerplants remain recognized for 2014, the Honda Accord’s peppy and fuel-efficient 3.5-liter V6 and the powerful supercharged 3.0-liter V6 featured in the Audi S5.
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
“We sell cars+ , if you don’t give us cars, naturally we won’t be able to go on, we’ll close,” Wang said in an interview, estimating import dealers are losing between 3 million and 10 million yuan a year each. The group seeking compensation represents 30 of the roughly 40 remaining imported Hyundai dealers in the country.
“I thought teaching wasn’t a proper career option. My teacher said I’d need to have a high boredom threshold if I wanted to become a teacher,” he recalls.
In July, a video of a couple having sex in the fitting room of a Uniqlo clothing store in Beijing took the Internet in China by storm. Some commenters speculated that it was a publicity stunt by the retailer, which denied the claim. Several people were detained on suspicion of uploading and distributing the video.
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
You`d love to know the balance of forces that shape and move your ponytail, right? That`s why Joseph Keller, Raymond Goldstein, Patrick Warren and Robin Ball received this igNOMINIOUS prize!
That's a fraction of their earning power -- Hillary and Bill Clinton banked $10.6 million mostly from speaking fees and royalties in 2015, while Trump said he made almost $560 million.
The value of goods that crossed international borders last year fell 13.8 per cent in dollar terms — the first contraction since 2009 — according to the Netherlands Bureau of Economic Policy Analysis’s World Trade Monitor. Much of the slump was due to a slowdown in China and other emerging economies.
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
《狼厅》(Wolf Hall)，PBS，4月5日播出。这一季最引人注目的选角，《国土安全》(Homeland)的主演达米恩·刘易斯(Damian Lewis)将在该剧中饰演亨利八世，两获托尼奖的马克·里朗斯(Mark Rylance)将饰演托马斯·克伦威尔(Thomas Cromwell)，这部经典改编剧改编自希拉里·曼特尔(Hilary Mantel)的畅销历史小说。
Among 36,000 who have reached celebrity status on the Internet, 74 percent are women and 87.8 percent are between 17 to 33 years old, while 89 percent have a college education. Followers are also getting younger and better educated, with 77.8 percent in the 17-to-33 age group and 75 percent with a higher education.
Inhibition of SARS coronavirus helicase by bismuth complexes
他们两个自称拥有着世界上最大的两个粉丝基础。但是周日晚上，在伦敦温布利SSE竞技场上举行的2017年欧洲音乐大奖中，Shawn Mendes夺得桂冠， Taylor Swift在她参选的五个奖项中纷纷落选。
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Local residents living near the launch sites have complained that the activists are putting their lives at risk by making them potential targets for North Korean retaliation.
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Wages will finally accelerate after years of stagnation
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
However, you know when your cycles are over when the washer and dryer stop making noise. And you know when the weather is ugly by simply looking outside, or checking your weather app. Therefore, the product is basically just another way hackers can get into your home.
"I am a doctor and I prefer to speak frankly. A person's health is related first to eating, drinking and air. Any kind of development will be nothing if the quality of food, water and air is not good." ZHONG NANSHAN, NPC deputy and academic with the Chinese Academy of Engineering
We were forced to leave our comfort zone but were rewarded with unique experiences, says one graduate.
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Two Chinese universities have been placed in the top 20 of this year's Times Higher Education World Reputation Rankings, according to data released last Thursday.
Yes — just. Democrats will regain control of the House of Representatives in the November midterm elections. Though they will not take charge until January 2019, they will waste no time preparing the House Judiciary paperwork. Mr Trump will label it a “witch hunt”. But another year of his surreal presidency makes it all but inevitable Democrats will campaign on a pledge to hold him to account. Whatever Robert Mueller’s investigation unearths before then is unlikely to turn enough Republicans against him.
No. One way it could play out: after a tentative start involving lots of trading stops, bitcoin futures will slowly begin to attract institutional money. Commodity Futures Trading Commission positioning data will reflect the extraordinary long bias that exists for the product among money managers. As the huge cost of rolling futures positions becomes self-evident, longs will complain ever more loudly about routine divergences around settlement time. Just as a senate hearing is being scheduled to investigate potential manipulation of the market, futures prices will fall below spot, initiating a sell-off.
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
在导演阿方索?卡隆(Alfonso Cuaron)和同事们（其中包括知名电影摄影师艾曼努尔?卢贝兹基(Emmanuel Lubezki)、制片设计师安迪?尼克尔森(Andy Nicholson)和编剧霍纳斯?卡隆(Jonas Cuaron)）的共同努力下，《地心引力》丰富了电影的拍摄手法。《美国电影摄影师》(American Cinematographer)杂志上个月的封面故事刊载了关于《地心引力》制作过程的文章，对电影技术感兴趣的读者可以一探究竟。读者们可以在网上阅读该杂志。不过任何看过《地心引力》的观众都已经领会到了该片的情感内涵，这部电影把观众们带进入了一个寂静危险的外太空和一个深度愉悦的内心世界。
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
We learned about the lingering toll of this frightening epidemic.
Taylor Swift “Blank Space” (Big Machine)
"We are also witnessing a positive progress of diversification," he said. "In the past, most Chinese companies' patent filings were concentrated in the ICT sector, but now there are increasingly patents filed in engines, turbines, sports, automotive, and biotechnology sectors."
"A total of 297 projects will be carried out in Tongzhou, such as building new subway lines and expressways, and improving ecologies," Lu Yan, director of the Beijing Municipal Commission of Development and Reform, said at a news conference on Wednesday.
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
The best bosses understand that there must be a balance between the company or client’s needs and the needs of his or her employees. The best bosses are willing to listen and talk about any issues an employee may be having because they understand that a happy employee is a more productive employee。
Online marketplace Amazon.com Inc made its debut in the 2015 Thomson Reuters Top 100 global innovators list, leaving International Business Machines Corp, the world's largest technology services company, out of the list.
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
According to the new report, over the past 20 years India has been the leading user of anti-dumping cases, filing 767, or 15 per cent, of the 4,990 initiated between 1995 and 2015. The US accounted for 570 while the EU registered 480.
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
8. Greenland sharks live for a very long time
"You can no longer have some countries go first and others come in later, because there is no more time," said Glen P. Peters, a scientist at the Center for International Climate and Environmental Research in Oslo, who helped compile the new numbers. "It needs to be all hands on deck now."
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
A Larger Profile
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
梅瑟威一场拳赛的要价可以高达7000万英镑，但是他去年的收入只排在榜单上位居第16位。去年梅瑟威的拳赛收入达到了2000万英镑，此外他的服装品牌TMT（The Money Team）也给他贡献了500万英镑。
The prices are tough for ordinary Brazilians to afford. The minimum wage in the country is $330 a month, just about what Ferreira said she earns.
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
For once, the Lakers are in good spot and don't have to rush into anything. Take some time. See what they have. They're not making the playoffs with that defense, but that's not really the point of this season anyway.
Goldie Hawn’s award for best supporting actress in the 1970 film Cactus Flower rests somewhere altogether more zen – in the “India Room” in which she likes to meditate. Hers isn’t the only award to apparently emit good vibes – Russell Crowe’s award for best actor, which he won for his role as the bang-on-trend, leather miniskirt clad Maximus Decimus Meridius in Ridley Scott’s 2000 film Gladiator, is kept in a chicken coop on the actor’s Australian ranch. Crowe apparently thinks it helps the hens lay bigger eggs.
A modular microarray imaging system for highly specific COVID-19 antibody testing
200911/88512.shtmlA love letter to a US college student from the girlfriend who was to become his wife is finally on its way to him - 53 years after it was written in 1958.
However, this year it is ranked in eighth place.
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
“气候变化也许是我们这代人的重大挑战，”美国国家航空航天局(NASA)地球科学部主任迈克尔·H·弗莱利赫(Michael H. Freilich)说，他的部门是跟踪全球气温的机构之一。
Yes. Mr Meade is the candidate of the ruling Institutional Revolutionary Party, or PRI. His main rival is the hard leftist Andrés Manuel López Obrador, a passionate orator who can work a crowd. Mr Meade has a lot to overcome: he will have to convince voters that they can trust him, after he put up petrol prices by 20 per cent overnight in January, triggering a surge in inflation. He will also have to reveal himself as his own man, not just a clone of an unpopular government that has failed spectacularly to rein in rampant corruption and crime. But backed by the formidable PRI get-out-the-vote machine, he could prove unstoppable. In Mexico’s one-round-only system, 30 per cent of the vote might be enough.
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
China will remain an important engine for world growth amid sluggish global economic recovery.
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
Payne, a former lottery pick, missed time with a foot injury and hasn't shown any major progress as a shooter or a defender in year two.
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
There are 27 companies that are dropped from the list this year, including AT&T, IBM, Siemens and Xerox.
7. Trust will remain the single most critical business issue.
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Song “Taste of China” (Phoenix Legend)
Tiger got to sleep, bird got to land;
A facile assay for rapid detection of COVID-19 antibodies
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
France, along with Belgium, has seen the largest numbers of volunteers leaving to join the Islamic State jihadist group, which has seized large parts of Syriaand Iraq.
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Those who graduated from Peking University and Beijing Foreign Studies University took second and third place, earning 9,042 yuan and 9,020 yuan a month, respectively.
Lawyers are inherently cautious but most have realised that technology is crucial to crunching through the vast amount of information they handle. Without it, certain document heavy processes, such as disclosure and compliance, would be nearly impossible.
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
China has ample foreign exchange reserves to satisfy the demands of imports and short-term debt repayments.
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
不过目前来看，这些潜在的乌云似乎都没有遮住特斯拉在帕洛阿尔托总部的阳光。特斯拉仍然坚持在2020年之前年产50万辆汽车的中期目标。这在很大程度上要取决于Model X是否有能力维持当前的势头。特斯拉已经大大提高了资本和研发支出，以确保Model X的顺利发布（虽然已经推迟了一年）。
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
"Quality supervision authorities at all levels must intensify quality supervision and keep cracking down on law violations to improve the quality of products and protect consumers' rights," said Mei Kebao, deputy head of the administration.
Anti-HIV drug repurposing against SARS-CoV-2
Hope all your New Year dreams come true!愿你所有的新年想都成真！
Harvey C Mansfield, one of Harvard's most outspoken conservative professors and the author of a book called Manliness, also told the Guardian he questioned the decision. "The bounds of what is offensive have been extended and distorted, and I no longer trust the bent judgment of politically correct enforcers."
The recovery may help allay some of the gloom around emerging market countries, many of which used strong export growth as a springboard for rapid economic advancement in the early years of this century, before the export boom turned to bust.
Length-scale dependence of protein hydration-shell density
The fear was over downward mobility and cultural changes; the anger was against immigrants and indifferent elites.
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Dua Lipa, 'Dua Lipa'
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
'How do I explain the fact that I got a GQ Man of the Year award and no women's magazines and no women's organisations have supported me?
There are 27 companies that are dropped from the list this year, including AT&T, IBM, Siemens and Xerox.
About this collection
The Datafolha poll was based on interviews with 693 fans at the Mineirao stadium in Belo Horizonte and had a statistical margin of error of 4 percentage points.
2.German: 22.2 percent increase